Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2227586..2228103 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag KU537_RS10730 Protein ID WP_000113265.1
Coordinates 2227837..2228103 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU537_RS10725 Protein ID WP_000584499.1
Coordinates 2227586..2227837 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS10695 (2223284) 2223284..2224003 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU537_RS10700 (2224000) 2224000..2224731 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU537_RS10705 (2224828) 2224828..2226078 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
KU537_RS10710 (2226333) 2226333..2226695 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KU537_RS10715 (2226714) 2226714..2227313 + 600 WP_000162810.1 DsbA family protein -
KU537_RS10720 (2227341) 2227341..2227421 + 81 WP_223197974.1 hypothetical protein -
KU537_RS10725 (2227586) 2227586..2227837 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU537_RS10730 (2227837) 2227837..2228103 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
KU537_RS10735 (2228138) 2228138..2228209 + 72 Protein_2111 hypothetical protein -
KU537_RS10740 (2228398) 2228398..2229945 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU537_RS10745 (2230131) 2230131..2230598 + 468 WP_000153347.1 SRPBCC domain-containing protein -
KU537_RS10750 (2230682) 2230682..2230864 + 183 WP_000230292.1 hypothetical protein -
KU537_RS10755 (2231081) 2231081..2231905 + 825 WP_000572038.1 formate/nitrite transporter family protein -
KU537_RS10760 (2232139) 2232139..2232675 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T208208 WP_000113265.1 NZ_CP077859:2227837-2228103 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208208 NZ_CP103592:2206046-2206148 [Escherichia coli O25b:H4-ST131]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208208 WP_000584499.1 NZ_CP077859:2227586-2227837 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208208 NZ_CP103592:c2206186-2205918 [Escherichia coli O25b:H4-ST131]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References