Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2227586..2228103 | Replicon | chromosome |
Accession | NZ_CP077859 | ||
Organism | Staphylococcus aureus strain AC5 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
Locus tag | KU537_RS10730 | Protein ID | WP_000113265.1 |
Coordinates | 2227837..2228103 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | KU537_RS10725 | Protein ID | WP_000584499.1 |
Coordinates | 2227586..2227837 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KU537_RS10695 (2223284) | 2223284..2224003 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
KU537_RS10700 (2224000) | 2224000..2224731 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
KU537_RS10705 (2224828) | 2224828..2226078 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
KU537_RS10710 (2226333) | 2226333..2226695 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
KU537_RS10715 (2226714) | 2226714..2227313 | + | 600 | WP_000162810.1 | DsbA family protein | - |
KU537_RS10720 (2227341) | 2227341..2227421 | + | 81 | WP_223197974.1 | hypothetical protein | - |
KU537_RS10725 (2227586) | 2227586..2227837 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KU537_RS10730 (2227837) | 2227837..2228103 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
KU537_RS10735 (2228138) | 2228138..2228209 | + | 72 | Protein_2111 | hypothetical protein | - |
KU537_RS10740 (2228398) | 2228398..2229945 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
KU537_RS10745 (2230131) | 2230131..2230598 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
KU537_RS10750 (2230682) | 2230682..2230864 | + | 183 | WP_000230292.1 | hypothetical protein | - |
KU537_RS10755 (2231081) | 2231081..2231905 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
KU537_RS10760 (2232139) | 2232139..2232675 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T208208 WP_000113265.1 NZ_CP077859:2227837-2228103 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208208 NZ_CP103592:2206046-2206148 [Escherichia coli O25b:H4-ST131]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208208 WP_000584499.1 NZ_CP077859:2227586-2227837 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208208 NZ_CP103592:c2206186-2205918 [Escherichia coli O25b:H4-ST131]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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