Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2202616..2202800 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KU537_RS10595 Protein ID WP_000482652.1
Coordinates 2202616..2202723 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2202740..2202800 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS10570 2197978..2198451 + 474 WP_000456486.1 GyrI-like domain-containing protein -
KU537_RS10575 2198574..2199785 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU537_RS10580 2199967..2200626 - 660 WP_000831298.1 membrane protein -
KU537_RS10585 2200686..2201828 - 1143 WP_225798608.1 glycerate kinase -
KU537_RS10590 2202096..2202482 + 387 WP_000779360.1 flippase GtxA -
KU537_RS10595 2202616..2202723 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2202740..2202800 - 61 - - Antitoxin
KU537_RS10600 2203425..2205188 + 1764 WP_001064825.1 ABC transporter ATP-binding protein -
KU537_RS10605 2205213..2206946 + 1734 WP_000486487.1 ABC transporter ATP-binding protein -
KU537_RS10610 2207213..2207344 + 132 WP_223197975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208206 WP_000482652.1 NZ_CP077859:2202616-2202723 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208206 NZ_CP103592:1933611-1933865 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 61 bp

>AT208206 NZ_CP077859:c2202800-2202740 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References