Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2504876..2505154 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag KU543_RS12280 Protein ID WP_001802298.1
Coordinates 2504876..2504980 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2504976..2505154 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS12265 2501673..2502455 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
KU543_RS12270 2502523..2503380 + 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
KU543_RS12275 2504038..2504196 - 159 WP_001792784.1 hypothetical protein -
KU543_RS12280 2504876..2504980 + 105 WP_001802298.1 hypothetical protein Toxin
- 2504976..2505154 - 179 - - Antitoxin
KU543_RS12290 2505413..2506504 - 1092 WP_000495669.1 hypothetical protein -
KU543_RS12295 2506770..2507747 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
KU543_RS12300 2507749..2508069 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
KU543_RS12305 2508221..2508886 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T208193 WP_001802298.1 NZ_CP077858:2504876-2504980 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T208193 NZ_CP103589:c4647216-4647043 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 179 bp

>AT208193 NZ_CP077858:c2505154-2504976 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References