Detailed information of TA system TA208192

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2504876..2505138
• Replicon: chromosome
• Accession: NZ_CP077858
• Organism: Staphylococcus aureus strain AC6

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU543_RS12280
• Protein ID: WP_001802298.1
• Coordinates: 2504876..2504980 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2504975..2505138 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU543_RS12265	2501673..2502455	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
KU543_RS12270	2502523..2503380	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
KU543_RS12275	2504038..2504196	-	159	WP_001792784.1	hypothetical protein	-
KU543_RS12280	2504876..2504980	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2504975..2505138	-	164	-	-	Antitoxin
KU543_RS12290	2505413..2506504	-	1092	WP_000495669.1	hypothetical protein	-
KU543_RS12295	2506770..2507747	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
KU543_RS12300	2507749..2508069	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU543_RS12305	2508221..2508886	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208192 WP_001802298.1 NZ_CP077858:2504876-2504980 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208192 NZ_CP103589:4635706-4636080 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT208192 NZ_CP077858:c2505138-2504975 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin