Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2244931..2245448 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag KU543_RS10935 Protein ID WP_000113265.1
Coordinates 2245182..2245448 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU543_RS10930 Protein ID WP_000584499.1
Coordinates 2244931..2245182 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS10900 (2240629) 2240629..2241348 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU543_RS10905 (2241345) 2241345..2242076 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU543_RS10910 (2242173) 2242173..2243423 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
KU543_RS10915 (2243678) 2243678..2244040 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KU543_RS10920 (2244059) 2244059..2244658 + 600 WP_000162810.1 DsbA family protein -
KU543_RS10925 (2244686) 2244686..2244766 + 81 WP_223197974.1 hypothetical protein -
KU543_RS10930 (2244931) 2244931..2245182 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU543_RS10935 (2245182) 2245182..2245448 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
KU543_RS10940 (2245483) 2245483..2245554 + 72 Protein_2121 hypothetical protein -
KU543_RS10945 (2245743) 2245743..2247290 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU543_RS10950 (2247476) 2247476..2247943 + 468 WP_000153347.1 SRPBCC domain-containing protein -
KU543_RS10955 (2248027) 2248027..2248209 + 183 WP_000230292.1 hypothetical protein -
KU543_RS10960 (2248426) 2248426..2249250 + 825 WP_000572038.1 formate/nitrite transporter family protein -
KU543_RS10965 (2249484) 2249484..2250020 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T208191 WP_000113265.1 NZ_CP077858:2245182-2245448 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208191 NZ_CP103589:4376337-4376594 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208191 WP_000584499.1 NZ_CP077858:2244931-2245182 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208191 NZ_CP103589:4376606-4377151 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References