Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2219961..2220145 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KU543_RS10800 Protein ID WP_000482652.1
Coordinates 2219961..2220068 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2220085..2220145 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS10775 2215323..2215796 + 474 WP_000456486.1 GyrI-like domain-containing protein -
KU543_RS10780 2215919..2217130 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU543_RS10785 2217312..2217971 - 660 WP_000831298.1 membrane protein -
KU543_RS10790 2218031..2219173 - 1143 WP_225798608.1 glycerate kinase -
KU543_RS10795 2219441..2219827 + 387 WP_000779360.1 flippase GtxA -
KU543_RS10800 2219961..2220068 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2220085..2220145 - 61 - - Antitoxin
KU543_RS10805 2220770..2222533 + 1764 WP_001064825.1 ABC transporter ATP-binding protein -
KU543_RS10810 2222558..2224291 + 1734 WP_000486487.1 ABC transporter ATP-binding protein -
KU543_RS10815 2224558..2224689 + 132 WP_223197975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208189 WP_000482652.1 NZ_CP077858:2219961-2220068 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208189 NZ_CP103589:4259493-4259645 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 61 bp

>AT208189 NZ_CP077858:c2220145-2220085 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References