208175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2504396..2504674 Replicon chromosome
Accession NZ_CP077857
Organism Staphylococcus aureus strain L4

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag KU533_RS12275 Protein ID WP_001802298.1
Coordinates 2504396..2504500 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2504496..2504674 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU533_RS12260 2501193..2501975 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
KU533_RS12265 2502043..2502900 + 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
KU533_RS12270 2503558..2503716 - 159 WP_001792784.1 hypothetical protein -
KU533_RS12275 2504396..2504500 + 105 WP_001802298.1 hypothetical protein Toxin
- 2504496..2504674 - 179 - - Antitoxin
KU533_RS12285 2504933..2506024 - 1092 WP_000495669.1 hypothetical protein -
KU533_RS12290 2506290..2507267 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
KU533_RS12295 2507269..2507589 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
KU533_RS12300 2507741..2508406 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T208175 WP_001802298.1 NZ_CP077857:2504396-2504500 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T208175 NZ_CP103589:c639615-639151 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 179 bp

>AT208175 NZ_CP077857:c2504674-2504496 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9


Antitoxin

Download structure file

References