Detailed information of TA system TA208171

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2219495..2219679
• Replicon: chromosome
• Accession: NZ_CP077857
• Organism: Staphylococcus aureus strain L4

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KU533_RS10795
• Protein ID: WP_000482652.1
• Coordinates: 2219495..2219602 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2219619..2219679 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU533_RS10770	2214857..2215330	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
KU533_RS10775	2215453..2216664	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU533_RS10780	2216846..2217505	-	660	WP_000831298.1	membrane protein	-
KU533_RS10785	2217565..2218707	-	1143	WP_225798608.1	glycerate kinase	-
KU533_RS10790	2218975..2219361	+	387	WP_000779360.1	flippase GtxA	-
KU533_RS10795	2219495..2219602	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2219619..2219679	-	61	-	-	Antitoxin
KU533_RS10800	2220304..2222067	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
KU533_RS10805	2222092..2223825	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
KU533_RS10810	2224092..2224223	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208171 WP_000482652.1 NZ_CP077857:2219495-2219602 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208171 NZ_CP103586:c4826269-4825985 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208171 NZ_CP077857:c2219679-2219619 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin