Detailed information of TA system TA208157

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2492349..2492627
• Replicon: chromosome
• Accession: NZ_CP077856
• Organism: Staphylococcus aureus strain L5

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU529_RS12105
• Protein ID: WP_001802298.1
• Coordinates: 2492349..2492453 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2492449..2492627 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU529_RS12090	2489146..2489928	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
KU529_RS12095	2489996..2490853	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
KU529_RS12100	2491511..2491669	-	159	WP_001792784.1	hypothetical protein	-
KU529_RS12105	2492349..2492453	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2492449..2492627	-	179	-	-	Antitoxin
KU529_RS12115	2492886..2493977	-	1092	WP_000495669.1	hypothetical protein	-
KU529_RS12120	2494243..2495220	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
KU529_RS12125	2495222..2495542	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU529_RS12130	2495694..2496359	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208157 WP_001802298.1 NZ_CP077856:2492349-2492453 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208157 NZ_CP103582:c4737744-4737460 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT208157 NZ_CP077856:c2492627-2492449 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin