Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2207448..2207632 Replicon chromosome
Accession NZ_CP077856
Organism Staphylococcus aureus strain L5

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KU529_RS10625 Protein ID WP_000482652.1
Coordinates 2207448..2207555 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2207572..2207632 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU529_RS10600 2202810..2203283 + 474 WP_000456486.1 GyrI-like domain-containing protein -
KU529_RS10605 2203406..2204617 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU529_RS10610 2204799..2205458 - 660 WP_000831298.1 membrane protein -
KU529_RS10615 2205518..2206660 - 1143 WP_225798608.1 glycerate kinase -
KU529_RS10620 2206928..2207314 + 387 WP_000779360.1 flippase GtxA -
KU529_RS10625 2207448..2207555 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2207572..2207632 - 61 - - Antitoxin
KU529_RS10630 2208257..2210020 + 1764 WP_001064825.1 ABC transporter ATP-binding protein -
KU529_RS10635 2210045..2211778 + 1734 WP_000486487.1 ABC transporter ATP-binding protein -
KU529_RS10640 2212045..2212176 + 132 WP_223197975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208153 WP_000482652.1 NZ_CP077856:2207448-2207555 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208153 NZ_CP103582:c3156971-3156795 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA

Antitoxin


Download         Length: 61 bp

>AT208153 NZ_CP077856:c2207632-2207572 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References