Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 16186..16444 Replicon chromosome
Accession NC_004431
Organism Escherichia coli CFT073

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C_RS00090 Protein ID WP_000809168.1
Coordinates 16186..16338 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 16387..16444 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C_RS00070 11431..12144 - 714 WP_001102391.1 acidic protein MsyB -
C_RS00075 12170..12574 - 405 WP_000843687.1 DUF2541 family protein -
C_RS00080 12946..14862 + 1917 WP_000516135.1 molecular chaperone DnaK -
C_RS00085 14951..16081 + 1131 WP_001118464.1 molecular chaperone DnaJ -
C_RS00090 16186..16338 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 16387..16444 + 58 - - Antitoxin
C_RS00095 16953..17714 + 762 WP_001274832.1 hypothetical protein -
C_RS00100 17734..19227 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
C_RS00105 19356..20615 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T20815 WP_000809168.1 NC_004431:c16338-16186 [Escherichia coli CFT073]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T20815 NC_004431:c16338-16186 [Escherichia coli CFT073]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT20815 NC_004431:16387-16444 [Escherichia coli CFT073]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References