Detailed information of TA system TA208149

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 55686..55866
• Replicon: chromosome
• Accession: NZ_CP077856
• Organism: Staphylococcus aureus strain L5

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU529_RS00335
• Protein ID: WP_001801861.1
• Coordinates: 55771..55866 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	55686..55743 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU529_RS00305	51395..51529	+	135	WP_001791797.1	hypothetical protein	-
KU529_RS00310	51693..53249	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
KU529_RS00315	53242..54471	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
KU529_RS00320	55013..55423	+	411	WP_001808705.1	IS21 family transposase	-
KU529_RS00325	55408..55569	+	162	Protein_56	transposase	-
KU529_RS00330	55547..55648	-	102	WP_001792025.1	hypothetical protein	-
-	55686..55743	+	58	-	-	Antitoxin
KU529_RS00335	55771..55866	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
KU529_RS00340	56011..57023	+	1013	Protein_59	IS3 family transposase	-
KU529_RS00345	57221..57793	-	573	WP_000414216.1	hypothetical protein	-
KU529_RS00350	57894..58235	-	342	WP_000627540.1	DUF3969 family protein	-
KU529_RS00355	58276..58902	-	627	WP_000669024.1	hypothetical protein	-
KU529_RS00360	58978..59973	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
KU529_RS00365	60054..60704	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	28853..79884	51031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208149 WP_001801861.1 NZ_CP077856:c55866-55771 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208149 NZ_CP103582:734449-734934 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTGCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCACAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208149 NZ_CP077856:55686-55743 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin