Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2756949..2757466 | Replicon | chromosome |
Accession | NZ_CP077855 | ||
Organism | Staphylococcus aureus strain L6 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
Locus tag | KU520_RS13695 | Protein ID | WP_000113265.1 |
Coordinates | 2757200..2757466 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | KU520_RS13690 | Protein ID | WP_000584499.1 |
Coordinates | 2756949..2757200 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KU520_RS13660 (2752647) | 2752647..2753366 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
KU520_RS13665 (2753363) | 2753363..2754094 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
KU520_RS13670 (2754191) | 2754191..2755441 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
KU520_RS13675 (2755696) | 2755696..2756058 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
KU520_RS13680 (2756077) | 2756077..2756676 | + | 600 | WP_000162810.1 | DsbA family protein | - |
KU520_RS13685 (2756704) | 2756704..2756784 | + | 81 | WP_223197974.1 | hypothetical protein | - |
KU520_RS13690 (2756949) | 2756949..2757200 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KU520_RS13695 (2757200) | 2757200..2757466 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
KU520_RS13700 (2757501) | 2757501..2757572 | + | 72 | Protein_2660 | hypothetical protein | - |
KU520_RS13705 (2757761) | 2757761..2759308 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
KU520_RS13710 (2759494) | 2759494..2759961 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
KU520_RS13715 (2760045) | 2760045..2760227 | + | 183 | WP_000230292.1 | hypothetical protein | - |
KU520_RS13720 (2760444) | 2760444..2761268 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
KU520_RS13725 (2761502) | 2761502..2762038 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T208147 WP_000113265.1 NZ_CP077855:2757200-2757466 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208147 NZ_CP103582:326904-327272 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208147 WP_000584499.1 NZ_CP077855:2756949-2757200 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208147 NZ_CP103582:326686-326907 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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