Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2756949..2757466 Replicon chromosome
Accession NZ_CP077855
Organism Staphylococcus aureus strain L6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag KU520_RS13695 Protein ID WP_000113265.1
Coordinates 2757200..2757466 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU520_RS13690 Protein ID WP_000584499.1
Coordinates 2756949..2757200 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU520_RS13660 (2752647) 2752647..2753366 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU520_RS13665 (2753363) 2753363..2754094 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU520_RS13670 (2754191) 2754191..2755441 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
KU520_RS13675 (2755696) 2755696..2756058 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KU520_RS13680 (2756077) 2756077..2756676 + 600 WP_000162810.1 DsbA family protein -
KU520_RS13685 (2756704) 2756704..2756784 + 81 WP_223197974.1 hypothetical protein -
KU520_RS13690 (2756949) 2756949..2757200 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU520_RS13695 (2757200) 2757200..2757466 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
KU520_RS13700 (2757501) 2757501..2757572 + 72 Protein_2660 hypothetical protein -
KU520_RS13705 (2757761) 2757761..2759308 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU520_RS13710 (2759494) 2759494..2759961 + 468 WP_000153347.1 SRPBCC domain-containing protein -
KU520_RS13715 (2760045) 2760045..2760227 + 183 WP_000230292.1 hypothetical protein -
KU520_RS13720 (2760444) 2760444..2761268 + 825 WP_000572038.1 formate/nitrite transporter family protein -
KU520_RS13725 (2761502) 2761502..2762038 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T208147 WP_000113265.1 NZ_CP077855:2757200-2757466 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208147 NZ_CP103582:326904-327272 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208147 WP_000584499.1 NZ_CP077855:2756949-2757200 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208147 NZ_CP103582:326686-326907 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References