Detailed information of TA system TA208145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2731979..2732163
• Replicon: chromosome
• Accession: NZ_CP077855
• Organism: Staphylococcus aureus strain L6

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KU520_RS13560
• Protein ID: WP_000482652.1
• Coordinates: 2731979..2732086 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2732103..2732163 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU520_RS13535	2727341..2727814	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
KU520_RS13540	2727937..2729148	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU520_RS13545	2729330..2729989	-	660	WP_000831298.1	membrane protein	-
KU520_RS13550	2730049..2731191	-	1143	WP_225798608.1	glycerate kinase	-
KU520_RS13555	2731459..2731845	+	387	WP_000779360.1	flippase GtxA	-
KU520_RS13560	2731979..2732086	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2732103..2732163	-	61	-	-	Antitoxin
KU520_RS13565	2732788..2734551	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
KU520_RS13570	2734576..2736309	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
KU520_RS13575	2736576..2736707	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208145 WP_000482652.1 NZ_CP077855:2731979-2732086 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208145 NZ_CP103579:c5192076-5191693 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208145 NZ_CP077855:c2732163-2732103 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin