Detailed information of TA system TA208123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 535033..535217
• Replicon: chromosome
• Accession: NZ_CP077854
• Organism: Staphylococcus aureus strain N4

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KU508_RS02900
• Protein ID: WP_000482652.1
• Coordinates: 535110..535217 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	535033..535093 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU508_RS02885	530489..530620	-	132	WP_223197975.1	hypothetical protein	-
KU508_RS02890	530887..532620	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
KU508_RS02895	532645..534408	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	535033..535093	+	61	-	-	Antitoxin
KU508_RS02900	535110..535217	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU508_RS02905	535351..535737	-	387	WP_000779360.1	flippase GtxA	-
KU508_RS02910	536005..537147	+	1143	WP_225798608.1	glycerate kinase	-
KU508_RS02915	537207..537866	+	660	WP_000831298.1	membrane protein	-
KU508_RS02920	538048..539259	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU508_RS02925	539382..539855	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208123 WP_000482652.1 NZ_CP077854:c535217-535110 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208123 NZ_CP103571:c164040-163624 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208123 NZ_CP077854:535033-535093 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin