Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 509730..510247 | Replicon | chromosome |
Accession | NZ_CP077854 | ||
Organism | Staphylococcus aureus strain N4 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
Locus tag | KU508_RS02765 | Protein ID | WP_000113265.1 |
Coordinates | 509730..509996 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | KU508_RS02770 | Protein ID | WP_000584499.1 |
Coordinates | 509996..510247 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KU508_RS02735 (505158) | 505158..505694 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
KU508_RS02740 (505928) | 505928..506752 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
KU508_RS02745 (506969) | 506969..507151 | - | 183 | WP_000230292.1 | hypothetical protein | - |
KU508_RS02750 (507235) | 507235..507702 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
KU508_RS02755 (507888) | 507888..509435 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
KU508_RS02760 (509624) | 509624..509695 | - | 72 | Protein_538 | hypothetical protein | - |
KU508_RS02765 (509730) | 509730..509996 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
KU508_RS02770 (509996) | 509996..510247 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KU508_RS02775 (510412) | 510412..510492 | - | 81 | WP_223197974.1 | hypothetical protein | - |
KU508_RS02780 (510520) | 510520..511119 | - | 600 | WP_000162810.1 | DsbA family protein | - |
KU508_RS02785 (511138) | 511138..511500 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
KU508_RS02790 (511755) | 511755..513005 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
KU508_RS02795 (513102) | 513102..513833 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
KU508_RS02800 (513830) | 513830..514549 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T208122 WP_000113265.1 NZ_CP077854:c509996-509730 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208122 NZ_CP103571:57412-57561 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208122 WP_000584499.1 NZ_CP077854:c510247-509996 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208122 NZ_CP103571:c57368-57307 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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