Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 509730..510247 Replicon chromosome
Accession NZ_CP077854
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag KU508_RS02765 Protein ID WP_000113265.1
Coordinates 509730..509996 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU508_RS02770 Protein ID WP_000584499.1
Coordinates 509996..510247 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU508_RS02735 (505158) 505158..505694 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KU508_RS02740 (505928) 505928..506752 - 825 WP_000572038.1 formate/nitrite transporter family protein -
KU508_RS02745 (506969) 506969..507151 - 183 WP_000230292.1 hypothetical protein -
KU508_RS02750 (507235) 507235..507702 - 468 WP_000153347.1 SRPBCC domain-containing protein -
KU508_RS02755 (507888) 507888..509435 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU508_RS02760 (509624) 509624..509695 - 72 Protein_538 hypothetical protein -
KU508_RS02765 (509730) 509730..509996 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
KU508_RS02770 (509996) 509996..510247 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU508_RS02775 (510412) 510412..510492 - 81 WP_223197974.1 hypothetical protein -
KU508_RS02780 (510520) 510520..511119 - 600 WP_000162810.1 DsbA family protein -
KU508_RS02785 (511138) 511138..511500 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU508_RS02790 (511755) 511755..513005 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
KU508_RS02795 (513102) 513102..513833 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU508_RS02800 (513830) 513830..514549 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T208122 WP_000113265.1 NZ_CP077854:c509996-509730 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208122 NZ_CP103571:57412-57561 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208122 WP_000584499.1 NZ_CP077854:c510247-509996 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208122 NZ_CP103571:c57368-57307 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References