Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2245443..2245960 | Replicon | chromosome |
| Accession | NZ_CP077853 | ||
| Organism | Staphylococcus aureus strain N5 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | KU499_RS10940 | Protein ID | WP_000113265.1 |
| Coordinates | 2245694..2245960 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KU499_RS10935 | Protein ID | WP_000584499.1 |
| Coordinates | 2245443..2245694 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU499_RS10905 (2241141) | 2241141..2241860 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| KU499_RS10910 (2241857) | 2241857..2242588 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KU499_RS10915 (2242685) | 2242685..2243935 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| KU499_RS10920 (2244190) | 2244190..2244552 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KU499_RS10925 (2244571) | 2244571..2245170 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| KU499_RS10930 (2245198) | 2245198..2245278 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| KU499_RS10935 (2245443) | 2245443..2245694 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KU499_RS10940 (2245694) | 2245694..2245960 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| KU499_RS10945 (2245995) | 2245995..2246066 | + | 72 | Protein_2122 | hypothetical protein | - |
| KU499_RS10950 (2246255) | 2246255..2247802 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KU499_RS10955 (2247988) | 2247988..2248455 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| KU499_RS10960 (2248539) | 2248539..2248721 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| KU499_RS10965 (2248938) | 2248938..2249762 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| KU499_RS10970 (2249996) | 2249996..2250532 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T208103 WP_000113265.1 NZ_CP077853:2245694-2245960 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208103 NZ_CP103570:865810-866217 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208103 WP_000584499.1 NZ_CP077853:2245443-2245694 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208103 NZ_CP103570:865563-865829 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|