Detailed information of TA system TA208101

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2220473..2220657
• Replicon: chromosome
• Accession: NZ_CP077853
• Organism: Staphylococcus aureus strain N5

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KU499_RS10805
• Protein ID: WP_000482652.1
• Coordinates: 2220473..2220580 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2220597..2220657 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU499_RS10780	2215835..2216308	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
KU499_RS10785	2216431..2217642	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU499_RS10790	2217824..2218483	-	660	WP_000831298.1	membrane protein	-
KU499_RS10795	2218543..2219685	-	1143	WP_225798608.1	glycerate kinase	-
KU499_RS10800	2219953..2220339	+	387	WP_000779360.1	flippase GtxA	-
KU499_RS10805	2220473..2220580	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2220597..2220657	-	61	-	-	Antitoxin
KU499_RS10810	2221282..2223045	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
KU499_RS10815	2223070..2224803	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
KU499_RS10820	2225070..2225201	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208101 WP_000482652.1 NZ_CP077853:2220473-2220580 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208101 NZ_CP103570:184326-184433 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208101 NZ_CP077853:c2220657-2220597 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin