Detailed information of TA system TA208093

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2703214..2703394
• Replicon: chromosome
• Accession: NZ_CP077852
• Organism: Staphylococcus aureus strain N6

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU516_RS13255
• Protein ID: WP_001801861.1
• Coordinates: 2703214..2703309 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2703337..2703394 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU516_RS13225	2698376..2699026	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
KU516_RS13230	2699107..2700102	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
KU516_RS13235	2700178..2700804	+	627	WP_000669024.1	hypothetical protein	-
KU516_RS13240	2700845..2701186	+	342	WP_000627540.1	DUF3969 family protein	-
KU516_RS13245	2701287..2701859	+	573	WP_000414216.1	hypothetical protein	-
KU516_RS13250	2702057..2703069	-	1013	Protein_2605	IS3 family transposase	-
KU516_RS13255	2703214..2703309	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2703337..2703394	-	58	-	-	Antitoxin
KU516_RS13260	2703432..2703533	+	102	WP_001792025.1	hypothetical protein	-
KU516_RS13265	2703511..2703672	-	162	Protein_2608	transposase	-
KU516_RS13270	2703657..2704067	-	411	WP_001808705.1	IS21 family transposase	-
KU516_RS13275	2704609..2705838	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
KU516_RS13280	2705831..2707387	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
KU516_RS13285	2707551..2707685	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208093 WP_001801861.1 NZ_CP077852:2703214-2703309 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208093 NZ_CP103567:939334-939744 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208093 NZ_CP077852:c2703394-2703337 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin