Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 551446..551630 Replicon chromosome
Accession NZ_CP077852
Organism Staphylococcus aureus strain N6

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KU516_RS02970 Protein ID WP_000482652.1
Coordinates 551523..551630 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 551446..551506 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU516_RS02955 546902..547033 - 132 WP_223197975.1 hypothetical protein -
KU516_RS02960 547300..549033 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
KU516_RS02965 549058..550821 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 551446..551506 + 61 - - Antitoxin
KU516_RS02970 551523..551630 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
KU516_RS02975 551764..552150 - 387 WP_000779360.1 flippase GtxA -
KU516_RS02980 552418..553560 + 1143 WP_225798608.1 glycerate kinase -
KU516_RS02985 553620..554279 + 660 WP_000831298.1 membrane protein -
KU516_RS02990 554461..555672 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU516_RS02995 555795..556268 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208089 WP_000482652.1 NZ_CP077852:c551630-551523 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208089 NZ_CP103564:21354-21602 [Escherichia coli O25b:H4-ST131]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTCTGGGGTATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 61 bp

>AT208089 NZ_CP077852:551446-551506 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References