Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 526143..526660 Replicon chromosome
Accession NZ_CP077852
Organism Staphylococcus aureus strain N6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag KU516_RS02835 Protein ID WP_000113265.1
Coordinates 526143..526409 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU516_RS02840 Protein ID WP_000584499.1
Coordinates 526409..526660 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU516_RS02805 (521571) 521571..522107 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KU516_RS02810 (522341) 522341..523165 - 825 WP_000572038.1 formate/nitrite transporter family protein -
KU516_RS02815 (523382) 523382..523564 - 183 WP_000230292.1 hypothetical protein -
KU516_RS02820 (523648) 523648..524115 - 468 WP_000153347.1 SRPBCC domain-containing protein -
KU516_RS02825 (524301) 524301..525848 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU516_RS02830 (526037) 526037..526108 - 72 Protein_549 hypothetical protein -
KU516_RS02835 (526143) 526143..526409 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
KU516_RS02840 (526409) 526409..526660 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU516_RS02845 (526825) 526825..526905 - 81 WP_223197974.1 hypothetical protein -
KU516_RS02850 (526933) 526933..527532 - 600 WP_000162810.1 DsbA family protein -
KU516_RS02855 (527551) 527551..527913 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU516_RS02860 (528168) 528168..529418 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
KU516_RS02865 (529515) 529515..530246 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU516_RS02870 (530243) 530243..530962 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T208088 WP_000113265.1 NZ_CP077852:c526409-526143 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208088 NZ_CP103564:19387-19638 [Escherichia coli O25b:H4-ST131]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208088 WP_000584499.1 NZ_CP077852:c526660-526409 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208088 NZ_CP103564:19625-19852 [Escherichia coli O25b:H4-ST131]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAGAAAGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAGGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References