Detailed information of TA system TA208086

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 266512..266728
• Replicon: chromosome
• Accession: NZ_CP077852
• Organism: Staphylococcus aureus strain N6

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU516_RS01490
• Protein ID: WP_001802298.1
• Coordinates: 266624..266728 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	266512..266567 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU516_RS01465	262718..263383	-	666	WP_001024095.1	SDR family oxidoreductase	-
KU516_RS01470	263535..263855	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU516_RS01475	263857..264834	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
KU516_RS01480	265100..266191	+	1092	WP_000495669.1	hypothetical protein	-
-	266512..266567	+	56	-	-	Antitoxin
KU516_RS01490	266624..266728	-	105	WP_001802298.1	hypothetical protein	Toxin
KU516_RS01495	267408..267566	+	159	WP_001792784.1	hypothetical protein	-
KU516_RS01500	268224..269081	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
KU516_RS01505	269149..269931	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208086 WP_001802298.1 NZ_CP077852:c266728-266624 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208086 NZ_CP103563:232411-232791 [Escherichia coli O25b:H4-ST131]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGACGGCCTGCCGGGAATGTC
TGATCCGGGTAAGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT208086 NZ_CP077852:266512-266567 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin