Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25726..26384 Replicon plasmid pDETAB8
Accession NZ_CP077847
Organism Acinetobacter baumannii strain DETAB-P24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU228_RS18920 Protein ID WP_000312250.1
Coordinates 26025..26384 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU228_RS18915 Protein ID WP_001096429.1
Coordinates 25726..26025 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU228_RS18870 (KU228_18800) 20759..21016 + 258 WP_000834292.1 hypothetical protein -
KU228_RS18875 (KU228_18805) 21021..21593 + 573 WP_000429351.1 hypothetical protein -
KU228_RS18880 (KU228_18810) 21569..21748 + 180 WP_002081921.1 hypothetical protein -
KU228_RS18885 (KU228_18815) 21765..22394 + 630 WP_002081923.1 hypothetical protein -
KU228_RS18890 (KU228_18820) 22434..22943 + 510 WP_001043199.1 hypothetical protein -
KU228_RS18895 (KU228_18825) 23024..23578 + 555 WP_000790085.1 hypothetical protein -
KU228_RS18900 (KU228_18830) 23628..24164 + 537 WP_106443595.1 hypothetical protein -
KU228_RS18905 (KU228_18835) 24787..25269 + 483 WP_223239263.1 hypothetical protein -
KU228_RS18910 (KU228_18840) 25362..25625 - 264 WP_000110863.1 hypothetical protein -
KU228_RS18915 (KU228_18845) 25726..26025 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
KU228_RS18920 (KU228_18850) 26025..26384 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU228_RS18925 (KU228_18855) 26585..27151 + 567 WP_000710385.1 hypothetical protein -
KU228_RS18930 (KU228_18860) 27200..27382 + 183 WP_000373385.1 hypothetical protein -
KU228_RS18935 (KU228_18865) 27449..28147 + 699 WP_106443613.1 hypothetical protein -
KU228_RS18940 (KU228_18870) 28286..28669 + 384 WP_062937159.1 hypothetical protein -
KU228_RS18945 (KU228_18875) 28736..29494 + 759 WP_001053129.1 hypothetical protein -
KU228_RS18950 (KU228_18880) 30564..30878 + 315 WP_000708714.1 hypothetical protein -
KU228_RS18955 (KU228_18885) 30914..31297 + 384 WP_223239266.1 molecular chaperone DnaJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70426 70426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T208068 WP_000312250.1 NZ_CP077847:c26384-26025 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T208068 NZ_CP103562:1976143-1976397 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT208068 WP_001096429.1 NZ_CP077847:c26025-25726 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT208068 NZ_CP103562:1975895-1976146 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References