Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 24261..24919 Replicon plasmid pDETAB16
Accession NZ_CP077841
Organism Acinetobacter baumannii strain DETAB-P90

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU251_RS20035 Protein ID WP_000312250.1
Coordinates 24560..24919 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU251_RS20030 Protein ID WP_001096429.1
Coordinates 24261..24560 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU251_RS19995 (KU251_19885) 20322..20579 + 258 WP_000834292.1 hypothetical protein -
KU251_RS20000 (KU251_19890) 20584..21156 + 573 WP_032011345.1 hypothetical protein -
KU251_RS20005 (KU251_19895) 21132..21311 + 180 WP_002081921.1 hypothetical protein -
KU251_RS20010 (KU251_19900) 21328..21957 + 630 WP_002081923.1 hypothetical protein -
KU251_RS20015 (KU251_19905) 21997..22506 + 510 WP_032018705.1 hypothetical protein -
KU251_RS20020 (KU251_19910) 22587..23141 + 555 WP_000790086.1 hypothetical protein -
KU251_RS20025 (KU251_19915) 23191..23727 + 537 WP_032010581.1 hypothetical protein -
KU251_RS20030 (KU251_19920) 24261..24560 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
KU251_RS20035 (KU251_19925) 24560..24919 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU251_RS20040 (KU251_19930) 25120..25686 + 567 WP_031948745.1 hypothetical protein -
KU251_RS20045 (KU251_19935) 25735..25965 + 231 WP_045124240.1 hypothetical protein -
KU251_RS20050 (KU251_19940) 25984..26682 + 699 WP_000873188.1 hypothetical protein -
KU251_RS20055 (KU251_19945) 26820..27203 + 384 WP_032018724.1 hypothetical protein -
KU251_RS20060 (KU251_19950) 27270..28028 + 759 WP_001053130.1 hypothetical protein -
KU251_RS20065 (KU251_19955) 28080..28415 + 336 WP_000654056.1 hypothetical protein -
KU251_RS20070 (KU251_19960) 29276..29590 + 315 WP_032011240.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70789 70789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T208063 WP_000312250.1 NZ_CP077841:c24919-24560 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T208063 NZ_CP103562:c643341-642877 [Escherichia coli O25b:H4-ST131]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT208063 WP_001096429.1 NZ_CP077841:c24560-24261 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT208063 NZ_CP103562:c643676-643341 [Escherichia coli O25b:H4-ST131]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References