Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 57546..58279 | Replicon | plasmid megaplasmid |
| Accession | NC_004349 | ||
| Organism | Shewanella oneidensis MR-1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q8E856 |
| Locus tag | SO_RS22460 | Protein ID | WP_011074398.1 |
| Coordinates | 57968..58279 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | Q8E857 |
| Locus tag | SO_RS22455 | Protein ID | WP_011074397.1 |
| Coordinates | 57546..57962 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SO_RS22425 | 52829..53988 | + | 1160 | WP_141135407.1 | IS3-like element ISSod1 family transposase | - |
| SO_RS22430 | 53996..54424 | - | 429 | Protein_59 | hypothetical protein | - |
| SO_RS22435 | 54504..55382 | - | 879 | WP_011074393.1 | hypothetical protein | - |
| SO_RS22440 | 55521..55808 | - | 288 | WP_011074394.1 | transcriptional regulator | - |
| SO_RS22445 | 55805..56140 | - | 336 | WP_011074395.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| SO_RS22450 | 56571..57275 | - | 705 | WP_011074396.1 | DUF2931 family protein | - |
| SO_RS22455 | 57546..57962 | - | 417 | WP_011074397.1 | transcriptional regulator | Antitoxin |
| SO_RS22460 | 57968..58279 | - | 312 | WP_011074398.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| SO_RS22465 | 58421..58657 | - | 237 | Protein_66 | IS5/IS1182 family transposase | - |
| SO_RS22470 | 58734..59492 | - | 759 | WP_011071076.1 | IS5-like element ISSod6 family transposase | - |
| SO_RS22475 | 59527..59880 | - | 354 | WP_164925946.1 | hypothetical protein | - |
| SO_RS22480 | 59873..60175 | - | 303 | WP_164925947.1 | hypothetical protein | - |
| SO_RS22485 | 60346..60981 | - | 636 | WP_011074400.1 | recombinase family protein | - |
| SO_RS22490 | 61181..61423 | + | 243 | WP_011074401.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| SO_RS22495 | 61416..61715 | + | 300 | WP_011074402.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| SO_RS22500 | 62110..62595 | - | 486 | WP_011074403.1 | immunity 26/phosphotriesterase HocA family protein | - |
| SO_RS22505 | 62700..62918 | - | 219 | Protein_74 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..161613 | 161613 | |
| - | inside | IScluster/Tn | - | - | 45061..76483 | 31422 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12254.87 Da Isoelectric Point: 10.0148
>T20806 WP_011074398.1 NC_004349:c58279-57968 [Shewanella oneidensis MR-1]
VHVISRKPFNDAAQKYPNDKDALVQIYSTLRSGTFTNPDDLRQVFPSLDNFKYRDKWWVIDVGGNNLRIIAFIEFRDNRM
YVKHVVSHADYSKLTDKYRRTKE
VHVISRKPFNDAAQKYPNDKDALVQIYSTLRSGTFTNPDDLRQVFPSLDNFKYRDKWWVIDVGGNNLRIIAFIEFRDNRM
YVKHVVSHADYSKLTDKYRRTKE
Download Length: 312 bp
>T20806 NC_004349:c58279-57968 [Shewanella oneidensis MR-1]
GTGCACGTTATTTCAAGAAAACCATTTAATGATGCCGCCCAAAAGTATCCTAACGATAAGGACGCTTTGGTGCAGATATA
CAGCACCTTACGCAGTGGCACATTCACCAATCCTGATGATTTACGACAAGTATTTCCGTCTTTAGATAACTTTAAATATC
GAGATAAATGGTGGGTAATTGATGTGGGAGGTAACAATCTACGCATTATCGCTTTCATCGAGTTCCGAGATAACAGGATG
TATGTGAAGCACGTGGTTAGCCATGCAGACTATAGCAAGCTGACTGATAAGTACCGTCGAACAAAGGAGTAA
GTGCACGTTATTTCAAGAAAACCATTTAATGATGCCGCCCAAAAGTATCCTAACGATAAGGACGCTTTGGTGCAGATATA
CAGCACCTTACGCAGTGGCACATTCACCAATCCTGATGATTTACGACAAGTATTTCCGTCTTTAGATAACTTTAAATATC
GAGATAAATGGTGGGTAATTGATGTGGGAGGTAACAATCTACGCATTATCGCTTTCATCGAGTTCCGAGATAACAGGATG
TATGTGAAGCACGTGGTTAGCCATGCAGACTATAGCAAGCTGACTGATAAGTACCGTCGAACAAAGGAGTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15476.67 Da Isoelectric Point: 4.2543
>AT20806 WP_011074397.1 NC_004349:c57962-57546 [Shewanella oneidensis MR-1]
MLPTACIEIREALAKVPYLAHIETQDDYEQALALMDDLVDDYDSNKFLIEMLSLSIERWEEQADEFAEFNAAIAEMDSGI
AVLKTLMAQYRLGVADLPELGSKSNVSKLLNAAEGKKLNRHHIEALSQRFGVPVSLFF
MLPTACIEIREALAKVPYLAHIETQDDYEQALALMDDLVDDYDSNKFLIEMLSLSIERWEEQADEFAEFNAAIAEMDSGI
AVLKTLMAQYRLGVADLPELGSKSNVSKLLNAAEGKKLNRHHIEALSQRFGVPVSLFF
Download Length: 417 bp
>AT20806 NC_004349:c57962-57546 [Shewanella oneidensis MR-1]
ATGCTACCTACTGCATGTATTGAAATTAGAGAAGCATTGGCCAAAGTGCCATACCTCGCGCACATTGAAACTCAGGACGA
CTACGAGCAAGCATTAGCATTAATGGACGATCTGGTTGATGATTACGACTCAAACAAATTTTTGATTGAGATGTTGTCAC
TTAGCATTGAGCGATGGGAAGAACAGGCTGATGAATTTGCTGAATTTAATGCAGCGATAGCCGAAATGGATAGTGGTATA
GCGGTATTGAAAACGCTTATGGCGCAGTATCGTCTTGGTGTTGCAGATCTTCCCGAATTAGGCTCAAAAAGTAATGTGAG
TAAGTTACTCAATGCCGCAGAAGGAAAGAAGCTTAATAGACACCACATTGAAGCACTCAGTCAGCGCTTTGGGGTGCCAG
TATCATTATTTTTTTAG
ATGCTACCTACTGCATGTATTGAAATTAGAGAAGCATTGGCCAAAGTGCCATACCTCGCGCACATTGAAACTCAGGACGA
CTACGAGCAAGCATTAGCATTAATGGACGATCTGGTTGATGATTACGACTCAAACAAATTTTTGATTGAGATGTTGTCAC
TTAGCATTGAGCGATGGGAAGAACAGGCTGATGAATTTGCTGAATTTAATGCAGCGATAGCCGAAATGGATAGTGGTATA
GCGGTATTGAAAACGCTTATGGCGCAGTATCGTCTTGGTGTTGCAGATCTTCCCGAATTAGGCTCAAAAAGTAATGTGAG
TAAGTTACTCAATGCCGCAGAAGGAAAGAAGCTTAATAGACACCACATTGAAGCACTCAGTCAGCGCTTTGGGGTGCCAG
TATCATTATTTTTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|