Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25725..26383 Replicon plasmid pDETAB7a
Accession NZ_CP077838
Organism Acinetobacter baumannii strain DETAB-E159

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU204_RS19335 Protein ID WP_000312250.1
Coordinates 26024..26383 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU204_RS19330 Protein ID WP_001096429.1
Coordinates 25725..26024 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU204_RS19285 (KU204_19200) 20758..21015 + 258 WP_000834292.1 hypothetical protein -
KU204_RS19290 (KU204_19205) 21020..21592 + 573 WP_038345812.1 hypothetical protein -
KU204_RS19295 (KU204_19210) 21568..21747 + 180 WP_002081921.1 hypothetical protein -
KU204_RS19300 (KU204_19215) 21764..22393 + 630 WP_002081923.1 hypothetical protein -
KU204_RS19305 (KU204_19220) 22433..22942 + 510 WP_001043199.1 hypothetical protein -
KU204_RS19310 (KU204_19225) 23023..23577 + 555 WP_038345807.1 hypothetical protein -
KU204_RS19315 (KU204_19230) 23627..24163 + 537 WP_000731981.1 hypothetical protein -
KU204_RS19320 (KU204_19235) 24786..25268 + 483 WP_001052677.1 hypothetical protein -
KU204_RS19325 (KU204_19240) 25361..25624 - 264 WP_000110863.1 hypothetical protein -
KU204_RS19330 (KU204_19245) 25725..26024 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
KU204_RS19335 (KU204_19250) 26024..26383 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU204_RS19340 (KU204_19255) 26584..27150 + 567 WP_000710385.1 hypothetical protein -
KU204_RS19345 (KU204_19260) 27199..27381 + 183 WP_000373385.1 hypothetical protein -
KU204_RS19350 (KU204_19265) 27448..28146 + 699 WP_000873188.1 hypothetical protein -
KU204_RS19355 (KU204_19270) 28285..28668 + 384 WP_000654348.1 hypothetical protein -
KU204_RS19360 (KU204_19275) 28735..29493 + 759 WP_001053128.1 hypothetical protein -
KU204_RS19365 (KU204_19280) 29545..29880 + 336 WP_000653925.1 hypothetical protein -
KU204_RS19370 (KU204_19285) 30747..31061 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..72258 72258


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T208059 WP_000312250.1 NZ_CP077838:c26383-26024 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T208059 NZ_CP103562:c46342-45968 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT208059 WP_001096429.1 NZ_CP077838:c26024-25725 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT208059 NZ_CP103562:c46800-46432 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References