Detailed information of TA system TA208047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2695806..2696374
• Replicon: chromosome
• Accession: NZ_CP077828
• Organism: Acinetobacter baumannii strain DETAB-E351

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KUY52_RS12780
• Protein ID: WP_236750196.1
• Coordinates: 2695806..2696060 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: A0A7M3FNJ1
• Locus tag: KUY52_RS12785
• Protein ID: WP_032053385.1
• Coordinates: 2696090..2696374 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUY52_RS12770 (KUY52_12740)	2694648..2695157	-	510	WP_038338751.1	hypothetical protein	-
KUY52_RS12775 (KUY52_12745)	2695280..2695624	-	345	WP_038338750.1	hypothetical protein	-
KUY52_RS12780 (KUY52_12750)	2695806..2696060	+	255	WP_236750196.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KUY52_RS12785 (KUY52_12755)	2696090..2696374	+	285	WP_032053385.1	HigA family addiction module antitoxin	Antitoxin
KUY52_RS12790 (KUY52_12760)	2696665..2697174	-	510	WP_038338755.1	hypothetical protein	-
KUY52_RS12795 (KUY52_12765)	2697245..2698162	-	918	WP_020752401.1	phage tail tube protein	-
KUY52_RS12800 (KUY52_12770)	2698257..2699240	-	984	WP_020752400.1	hypothetical protein	-
KUY52_RS12805 (KUY52_12775)	2699240..2699590	-	351	WP_020752399.1	hypothetical protein	-
KUY52_RS12810 (KUY52_12780)	2699686..2699904	-	219	WP_020752398.1	hypothetical protein	-
KUY52_RS12815 (KUY52_12785)	2699906..2700349	-	444	WP_171259867.1	phage tail terminator-like protein	-
KUY52_RS12820 (KUY52_12790)	2700306..2700674	-	369	WP_000539749.1	hypothetical protein	-
KUY52_RS12825 (KUY52_12795)	2700646..2701056	-	411	WP_000248411.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-84)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9611.74 Da
• Isoelectric Point: 6.4772

>T208047 WP_236750196.1 NZ_CP077828:2695806-2696060 [Acinetobacter baumannii]
MQAFFEEGSTAGIQAAHSKKLRLLLASLNAATSVYDLRTPPNWRLHELKGNLEGHWSLTVNGNWRVTFKFEDGDAYIVDY
QDYH

Nucleotide

• Length: 255 bp

>T208047 NZ_CP103560:350241-350588 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10330.89 Da
• Isoelectric Point: 7.3174

>AT208047 WP_032053385.1 NZ_CP077828:2696090-2696374 [Acinetobacter baumannii]
MKVMFNAPHPGEILQEYLEGISVTSAARALGVTRANLSRILNGHTGISADMALRLSEALSTSPEFWLNLQVQYDLWIASQ
NKRPTIQHLAPAMA

Nucleotide

• Length: 285 bp

>AT208047 NZ_CP103560:350588-350887 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7M3FNJ1