Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2352837..2353526 Replicon chromosome
Accession NZ_CP077823
Organism Klebsiella africana strain FF1019

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag KU660_RS11480 Protein ID WP_021469727.1
Coordinates 2352837..2353154 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU660_RS11485 Protein ID WP_004180116.1
Coordinates 2353230..2353526 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU660_RS11460 (2349126) 2349126..2350322 - 1197 WP_251355137.1 L-talarate/galactarate dehydratase -
KU660_RS11465 (2350627) 2350627..2351631 + 1005 WP_136032719.1 LacI family DNA-binding transcriptional regulator -
KU660_RS11470 (2351715) 2351715..2352332 + 618 WP_251355138.1 glutathione S-transferase family protein -
KU660_RS11475 (2352403) 2352403..2352630 + 228 WP_136032724.1 tautomerase PptA -
KU660_RS11480 (2352837) 2352837..2353154 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU660_RS11485 (2353230) 2353230..2353526 + 297 WP_004180116.1 NadS family protein Antitoxin
KU660_RS11490 (2353605) 2353605..2354051 + 447 WP_251355139.1 hypothetical protein -
KU660_RS11495 (2354092) 2354092..2355708 - 1617 WP_136032729.1 carbohydrate porin -
KU660_RS11500 (2355752) 2355752..2357134 - 1383 WP_136032731.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T208020 WP_021469727.1 NZ_CP077823:2352837-2353154 [Klebsiella africana]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

>T208020 NZ_CP103559:215674-215781 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11038.87 Da        Isoelectric Point: 7.3197

>AT208020 WP_004180116.1 NZ_CP077823:2353230-2353526 [Klebsiella africana]
MKDELFADLLASAEEMVRIEKGEQMPKEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp

>AT208020 NZ_CP103559:c215625-215562 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure

References