Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 360114..360760 Replicon chromosome
Accession NZ_CP077823
Organism Klebsiella africana strain FF1019

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU660_RS01645 Protein ID WP_136033730.1
Coordinates 360114..360461 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU660_RS01650 Protein ID WP_136033728.1
Coordinates 360461..360760 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU660_RS01635 (356001) 356001..357434 + 1434 WP_251354735.1 glycogen synthase GlgA -
KU660_RS01640 (357452) 357452..359899 + 2448 WP_025710771.1 glycogen phosphorylase -
KU660_RS01645 (360114) 360114..360461 + 348 WP_136033730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU660_RS01650 (360461) 360461..360760 + 300 WP_136033728.1 helix-turn-helix transcriptional regulator Antitoxin
KU660_RS01655 (360823) 360823..362331 - 1509 WP_008806993.1 glycerol-3-phosphate dehydrogenase -
KU660_RS01660 (362536) 362536..362865 + 330 WP_136033726.1 thiosulfate sulfurtransferase GlpE -
KU660_RS01665 (362916) 362916..363746 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KU660_RS01670 (363796) 363796..364554 + 759 WP_136033724.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13504.56 Da        Isoelectric Point: 6.7217

>T208007 WP_136033730.1 NZ_CP077823:360114-360461 [Klebsiella africana]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSKHLTKER

Download         Length: 348 bp

>T208007 NZ_CP103557:c4305369-4305085 [Escherichia coli O25b:H4-ST131]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10880.67 Da        Isoelectric Point: 10.1465

>AT208007 WP_136033728.1 NZ_CP077823:360461-360760 [Klebsiella africana]
MATLKELMAKQNPESQQRIAAKAAEIRQSVALNLLREELHMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT208007 NZ_CP103557:c4305605-4305372 [Escherichia coli O25b:H4-ST131]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References