207971

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4555244..4555890 Replicon chromosome
Accession NZ_CP077816
Organism Klebsiella pneumoniae strain FF1043

Toxin (Protein)


Gene name higB Uniprot ID A0A486RBU5
Locus tag KU669_RS22055 Protein ID WP_032410616.1
Coordinates 4555244..4555591 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag KU669_RS22060 Protein ID WP_002920557.1
Coordinates 4555591..4555890 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU669_RS22045 (KU669_22005) 4551170..4552603 + 1434 WP_002920564.1 glycogen synthase GlgA -
KU669_RS22050 (KU669_22010) 4552621..4555068 + 2448 WP_002920561.1 glycogen phosphorylase -
KU669_RS22055 (KU669_22015) 4555244..4555591 + 348 WP_032410616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU669_RS22060 (KU669_22020) 4555591..4555890 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
KU669_RS22065 (KU669_22025) 4555953..4557461 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
KU669_RS22070 (KU669_22030) 4557666..4557995 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KU669_RS22075 (KU669_22035) 4558046..4558876 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KU669_RS22080 (KU669_22040) 4558926..4559684 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.55 Da        Isoelectric Point: 5.6802

>T207971 WP_032410616.1 NZ_CP077816:4555244-4555591 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T207971 NZ_CP103550:4818521-4818805 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT207971 WP_002920557.1 NZ_CP077816:4555591-4555890 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT207971 NZ_CP103550:4818289-4818531 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RBU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References