Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4330999..4331645 Replicon chromosome
Accession NZ_CP077812
Organism Klebsiella pneumoniae strain FF1083

Toxin (Protein)


Gene name higB Uniprot ID A0A6G4MDN2
Locus tag KU672_RS20920 Protein ID WP_064148407.1
Coordinates 4330999..4331325 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU672_RS20925 Protein ID WP_064148406.1
Coordinates 4331346..4331645 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU672_RS20910 (4326925) 4326925..4328358 + 1434 WP_002920564.1 glycogen synthase GlgA -
KU672_RS20915 (4328376) 4328376..4330823 + 2448 WP_002920561.1 glycogen phosphorylase -
KU672_RS20920 (4330999) 4330999..4331325 + 327 WP_064148407.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU672_RS20925 (4331346) 4331346..4331645 + 300 WP_064148406.1 helix-turn-helix transcriptional regulator Antitoxin
KU672_RS20930 (4331708) 4331708..4333216 - 1509 WP_064148405.1 glycerol-3-phosphate dehydrogenase -
KU672_RS20935 (4333421) 4333421..4333750 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KU672_RS20940 (4333801) 4333801..4334631 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KU672_RS20945 (4334681) 4334681..4335439 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(31-84)


Sequences


Toxin        


Download         Length: 109 a.a.        Molecular weight: 12625.53 Da        Isoelectric Point: 5.1769

>T207927 WP_064148407.1 NZ_CP077812:4330999-4331325 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFS

Download         Length: 327 bp

>T207927 NZ_CP103544:999754-1000089 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10809.60 Da        Isoelectric Point: 10.1465

>AT207927 WP_064148406.1 NZ_CP077812:4331346-4331645 [Klebsiella pneumoniae]
MATLKELMAKHSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT207927 NZ_CP103544:999506-999754 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGAGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6G4MDN2


Antitoxin

Source ID Structure

References