Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4936537..4937183 Replicon chromosome
Accession NZ_CP077809
Organism Klebsiella pneumoniae strain FF923

Toxin (Protein)


Gene name higB Uniprot ID A6TF46
Locus tag KU666_RS24230 Protein ID WP_015959099.1
Coordinates 4936836..4937183 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag KU666_RS24225 Protein ID WP_004174017.1
Coordinates 4936537..4936836 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU666_RS24205 (4932743) 4932743..4933501 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
KU666_RS24210 (4933551) 4933551..4934381 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KU666_RS24215 (4934432) 4934432..4934761 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KU666_RS24220 (4934966) 4934966..4936474 + 1509 WP_117082713.1 glycerol-3-phosphate dehydrogenase -
KU666_RS24225 (4936537) 4936537..4936836 - 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
KU666_RS24230 (4936836) 4936836..4937183 - 348 WP_015959099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU666_RS24235 (4937359) 4937359..4939806 - 2448 WP_002920561.1 glycogen phosphorylase -
KU666_RS24240 (4939824) 4939824..4941257 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13519.49 Da        Isoelectric Point: 6.2327

>T207890 WP_015959099.1 NZ_CP077809:c4937183-4936836 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMNTLADREFSQHLTKER

Download         Length: 348 bp

>T207890 NZ_CP103533:2099680-2099783 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT207890 WP_004174017.1 NZ_CP077809:c4936836-4936537 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT207890 NZ_CP103533:c2099821-2099550 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TF46

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References