Detailed information of TA system TA207830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2332758..2333352
• Replicon: chromosome
• Accession: NZ_CP077803
• Organism: Rhodospirillum rubrum strain DSM 467

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q2RSS5
• Locus tag: KUL73_RS10450
• Protein ID: WP_011389773.1
• Coordinates: 2333071..2333352 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KUL73_RS10445
• Protein ID: WP_011389772.1
• Coordinates: 2332758..2333057 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUL73_RS10415 (KUL73_10415)	2328340..2329944	-	1605	WP_011389767.1	ABC transporter substrate-binding protein	-
KUL73_RS10420 (KUL73_10420)	2330243..2331244	+	1002	WP_011389768.1	DnaJ C-terminal domain-containing protein	-
KUL73_RS10425 (KUL73_10425)	2331241..2331579	+	339	WP_011389769.1	chaperone modulator CbpM	-
KUL73_RS10435 (KUL73_10435)	2331856..2332038	-	183	WP_207187479.1	hypothetical protein	-
KUL73_RS10440 (KUL73_10440)	2332180..2332569	+	390	WP_011389771.1	type II toxin-antitoxin system HicB family antitoxin	-
KUL73_RS10445 (KUL73_10445)	2332758..2333057	-	300	WP_011389772.1	HigA family addiction module antitoxin	Antitoxin
KUL73_RS10450 (KUL73_10450)	2333071..2333352	-	282	WP_011389773.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KUL73_RS10455 (KUL73_10455)	2333796..2334572	-	777	WP_207187480.1	endonuclease/exonuclease/phosphatase family protein	-
KUL73_RS10460 (KUL73_10460)	2334742..2334954	+	213	WP_011389775.1	hypothetical protein	-
KUL73_RS10465 (KUL73_10465)	2335406..2337877	+	2472	WP_011389776.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10852.29 Da
• Isoelectric Point: 8.1381

>T207830 WP_011389773.1 NZ_CP077803:c2333352-2333071 [Rhodospirillum rubrum]
MIRSFADKDTEGLFHGRFARKLPHDIQRIAQRKLRQIHAAEVLTDLRAPPGNHLEALQRDRAGQHSIRINDQWRICFVWK
DGGAEDVEIVDYH

Nucleotide

• Length: 282 bp

>T207830 NZ_CP103521:1919259-1919513 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11242.93 Da
• Isoelectric Point: 5.8632

>AT207830 WP_011389772.1 NZ_CP077803:c2333057-2332758 [Rhodospirillum rubrum]
MTIRDLSPVHPGEQLREEFMKPLKISAYKLAKDIDVPVSRIQDLAAERRSVTGDTALRLSRYFGTTPEFWLNMQRDFDLE
VAEIAVGDQIIAKVQPRAA

Nucleotide

• Length: 300 bp

>AT207830 NZ_CP103521:1919011-1919262 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: Q2RSS5