Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 55379..55964 | Replicon | plasmid unnamed |
| Accession | NZ_CP077802 | ||
| Organism | Acinetobacter baumannii strain 40288 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7S7BY50 |
| Locus tag | KUE09_RS19855 | Protein ID | WP_000897311.1 |
| Coordinates | 55379..55699 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KUE09_RS19860 | Protein ID | WP_000369784.1 |
| Coordinates | 55692..55964 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUE09_RS19835 (KUE09_19835) | 51186..51515 | + | 330 | WP_000506885.1 | DUF4236 domain-containing protein | - |
| KUE09_RS19840 (KUE09_19840) | 51787..53019 | - | 1233 | WP_001255535.1 | ATP-binding protein | - |
| KUE09_RS19845 (KUE09_19845) | 53277..53714 | - | 438 | Protein_49 | IS3 family transposase | - |
| KUE09_RS19850 (KUE09_19850) | 53768..54700 | + | 933 | WP_000743272.1 | IS5-like element IS17 family transposase | - |
| KUE09_RS19855 (KUE09_19855) | 55379..55699 | + | 321 | WP_000897311.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KUE09_RS19860 (KUE09_19860) | 55692..55964 | + | 273 | WP_000369784.1 | NadS family protein | Antitoxin |
| KUE09_RS19865 (KUE09_19865) | 55997..56797 | + | 801 | WP_000604996.1 | DUF2971 domain-containing protein | - |
| KUE09_RS19870 (KUE09_19870) | 56888..57189 | + | 302 | Protein_54 | IS3 family transposase | - |
| KUE09_RS19875 (KUE09_19875) | 57305..57517 | + | 213 | WP_001123161.1 | hypothetical protein | - |
| KUE09_RS19880 (KUE09_19880) | 57843..58700 | - | 858 | WP_000609033.1 | LysR family transcriptional regulator | - |
| KUE09_RS19885 (KUE09_19885) | 58697..59098 | - | 402 | Protein_57 | hydroxyacid dehydrogenase | - |
| KUE09_RS19890 (KUE09_19890) | 59163..59867 | + | 705 | WP_001067790.1 | IS6-like element IS1008 family transposase | - |
| KUE09_RS19895 (KUE09_19895) | 59918..60097 | - | 180 | Protein_59 | IS6 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul2 / tet(B) / aph(6)-Id / aph(3'')-Ib / aac(6')-Ian / aac(3)-IIa | - | 1..145711 | 145711 | |
| - | inside | IScluster/Tn | aac(6')-Ian / aac(3)-IIa | - | 53277..65515 | 12238 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12214.03 Da Isoelectric Point: 7.9500
>T207823 WP_000897311.1 NZ_CP077802:55379-55699 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG
Download Length: 321 bp
>T207823 NZ_CP103521:c625047-624583 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10145.57 Da Isoelectric Point: 7.0146
>AT207823 WP_000369784.1 NZ_CP077802:55692-55964 [Acinetobacter baumannii]
MDNNLFDDLVTSIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI
MDNNLFDDLVTSIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI
Download Length: 273 bp
>AT207823 NZ_CP103521:c625382-625047 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|