Detailed information of TA system TA207790

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 29148..29417
• Replicon: plasmid pCDI694-140.8
• Accession: NZ_CP077777
• Organism: Klebsiella pneumoniae strain CDI694

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KUM43_RS27790
• Protein ID: WP_001372321.1
• Coordinates: 29292..29417 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	29148..29213 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUM43_RS27765	24858..25385	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
KUM43_RS27770	25443..25676	+	234	WP_000006003.1	DUF905 family protein	-
KUM43_RS27775	25737..27760	+	2024	Protein_34	ParB/RepB/Spo0J family partition protein	-
KUM43_RS27780	27829..28263	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
KUM43_RS27785	28260..28979	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	28991..29215	+	225	NuclAT_0	-	-
-	28991..29215	+	225	NuclAT_0	-	-
-	28991..29215	+	225	NuclAT_0	-	-
-	28991..29215	+	225	NuclAT_0	-	-
-	29148..29213	-	66	-	-	Antitoxin
KUM43_RS29905	29201..29350	+	150	Protein_37	plasmid maintenance protein Mok	-
KUM43_RS27790	29292..29417	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KUM43_RS27795	29736..30032	-	297	Protein_39	hypothetical protein	-
KUM43_RS27800	30332..30628	+	297	WP_001272251.1	hypothetical protein	-
KUM43_RS27805	30739..31560	+	822	WP_001234445.1	DUF932 domain-containing protein	-
KUM43_RS27810	31857..32504	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
KUM43_RS27815	32781..33164	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
KUM43_RS27820	33355..34037	+	683	Protein_44	PAS domain-containing protein	-
KUM43_RS27825	34131..34358	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-65 / blaSHV-12 / blaKPC-2	-	1..140828	140828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T207790 WP_001372321.1 NZ_CP077777:29292-29417 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T207790 NZ_CP103512:c5382501-5382118 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT207790 NZ_CP077777:c29213-29148 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin