Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741338..742113 Replicon chromosome
Accession NZ_CP077773
Organism Klebsiella pneumoniae strain CDI694

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag KUM43_RS03705 Protein ID WP_004150910.1
Coordinates 741628..742113 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag KUM43_RS03700 Protein ID WP_004150912.1
Coordinates 741338..741631 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM43_RS03680 (KUM43_03680) 736546..737148 - 603 WP_062954968.1 short chain dehydrogenase -
KUM43_RS03685 (KUM43_03685) 737246..738157 + 912 WP_004188550.1 LysR family transcriptional regulator -
KUM43_RS03690 (KUM43_03690) 738158..739306 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
KUM43_RS03695 (KUM43_03695) 739317..740693 - 1377 WP_004217775.1 cystathionine beta-synthase -
KUM43_RS03700 (KUM43_03700) 741338..741631 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
KUM43_RS03705 (KUM43_03705) 741628..742113 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
KUM43_RS03710 (KUM43_03710) 742817..743410 + 594 WP_004188553.1 hypothetical protein -
KUM43_RS03715 (KUM43_03715) 743507..743723 + 217 Protein_730 transposase -
KUM43_RS03720 (KUM43_03720) 744329..745201 + 873 WP_004188557.1 ParA family protein -
KUM43_RS03725 (KUM43_03725) 745201..745584 + 384 WP_004150906.1 hypothetical protein -
KUM43_RS03730 (KUM43_03730) 745577..746944 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743507..743659 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T207774 WP_004150910.1 NZ_CP077773:741628-742113 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T207774 NZ_CP103508:c4160680-4160393 [Escherichia coli O25b:H4-ST131]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT207774 WP_004150912.1 NZ_CP077773:741338-741631 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT207774 NZ_CP103508:c4160406-4160104 [Escherichia coli O25b:H4-ST131]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References