Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2360865..2361619 | Replicon | chromosome |
| Accession | NZ_CP077760 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | KTV86_RS11425 | Protein ID | WP_000558168.1 |
| Coordinates | 2360865..2361176 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KTV86_RS11430 | Protein ID | WP_001259009.1 |
| Coordinates | 2361173..2361619 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTV86_RS11395 (2356523) | 2356523..2357425 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| KTV86_RS11400 (2357422) | 2357422..2358057 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| KTV86_RS11405 (2358054) | 2358054..2358983 | + | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
| KTV86_RS11410 (2359030) | 2359030..2359320 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| KTV86_RS11415 (2359321) | 2359321..2359632 | - | 312 | WP_001159636.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| KTV86_RS11420 (2359850) | 2359850..2360779 | + | 930 | WP_000171444.1 | alpha/beta hydrolase | - |
| KTV86_RS11425 (2360865) | 2360865..2361176 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| KTV86_RS11430 (2361173) | 2361173..2361619 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| KTV86_RS11435 (2361634) | 2361634..2362575 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| KTV86_RS11440 (2362620) | 2362620..2363057 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| KTV86_RS11445 (2363054) | 2363054..2363926 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| KTV86_RS11450 (2363920) | 2363920..2364519 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| KTV86_RS11455 (2364710) | 2364710..2365513 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| KTV86_RS11460 (2365547) | 2365547..2366443 | - | 897 | Protein_2233 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T207743 WP_000558168.1 NZ_CP077760:2360865-2361176 [Salmonella enterica subsp. enterica serovar Gallinarum]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T207743 NZ_CP103503:355709-356077 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT207743 WP_001259009.1 NZ_CP077760:2361173-2361619 [Salmonella enterica subsp. enterica serovar Gallinarum]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT207743 NZ_CP103503:355491-355712 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|