Detailed information of TA system TA207742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2359030..2359632
• Replicon: chromosome
• Accession: NZ_CP077760
• Organism: Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5RFE0
• Locus tag: KTV86_RS11415
• Protein ID: WP_001159636.1
• Coordinates: 2359321..2359632 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KTV86_RS11410
• Protein ID: WP_000362050.1
• Coordinates: 2359030..2359320 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTV86_RS11395 (2356523)	2356523..2357425	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
KTV86_RS11400 (2357422)	2357422..2358057	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KTV86_RS11405 (2358054)	2358054..2358983	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
KTV86_RS11410 (2359030)	2359030..2359320	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
KTV86_RS11415 (2359321)	2359321..2359632	-	312	WP_001159636.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
KTV86_RS11420 (2359850)	2359850..2360779	+	930	WP_000171444.1	alpha/beta hydrolase	-
KTV86_RS11425 (2360865)	2360865..2361176	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
KTV86_RS11430 (2361173)	2361173..2361619	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
KTV86_RS11435 (2361634)	2361634..2362575	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KTV86_RS11440 (2362620)	2362620..2363057	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
KTV86_RS11445 (2363054)	2363054..2363926	-	873	WP_000921423.1	virulence factor BrkB family protein	-
KTV86_RS11450 (2363920)	2363920..2364519	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12358.33 Da
• Isoelectric Point: 9.4460

>T207742 WP_001159636.1 NZ_CP077760:c2359632-2359321 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMMNERW

Nucleotide

• Length: 312 bp

>T207742 NZ_CP103501:37828-38139 [Klebsiella pneumoniae]
GTGCATGTTATATCACGAGCCCCTTTTGATGAGGCGGCGAGACACTATCCGAATGATGCTGCGGCCATCGATGACACCTA
TCGAGTACTAAAGCGTGTTGTCGCAAAAAAACCGGATGAGCTAAAGCGATACTTTACTAGTCTGGATCGCATGAAATACC
GGGAAAAATGGTGGGTTATCGATATCGGCGGTAATAACCTTAGAATGATGTTTTTTGCTGATTTTGAGCGCGGAAAGATA
TTCGTCAAACACATAACCACCCATGCTGAATATGATCGCTTAACGAAATATTATCGGGAGCACAAAGAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT207742 WP_000362050.1 NZ_CP077760:c2359320-2359030 [Salmonella enterica subsp. enterica serovar Gallinarum]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT207742 NZ_CP103501:38136-38552 [Klebsiella pneumoniae]
ATGATTTTTAGCGATGCCATTAAAGCGGCGAATGACCTGGCGAGTATTGTCCCTCTGCTGGGTGGCAGTTCGTCCCGCAA
AGATTACGAAGAGGCACTTAAACTCGTTGAATATCTTCTGGAACATGAGCCGGACAGCCCGCTGGTTGATATGCTGACTG
CCCGCATTGATGCCTGGGAAGATACCGCGGTGGAATTTGAAGAATTTAATACGCGTATCGAAGCTGGTAAAAACGGTGTA
TCGTTGCTACGGGTTCTCATGCAGCAACGCGGGCTTTCACAGTCCGATTTTGAAAACGAGATAGGCAAAAAATCGCTCGT
CAGCCGGATCCTCAGTGGTGAACGCAGTTTGACCCTTGATCACATGCGTGCGCTGGCAAATCGATTTCAAATCCCGGTCT
CGATGTTTGTTGACTGA

Structures

Toxin

• AlphaFold DB: B5RFE0