Detailed information of TA system TA207722

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2796014..2796593
• Replicon: chromosome
• Accession: NZ_CP077757
• Organism: Staphylococcus aureus strain WHC07

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: KTR68_RS13780
• Protein ID: WP_001025401.1
• Coordinates: 2796014..2796259 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2796228..2796593 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR68_RS13725	2791257..2791403	-	147	WP_113342690.1	hypothetical protein	-
KTR68_RS13730	2791607..2791948	-	342	WP_000591749.1	hypothetical protein	-
KTR68_RS13735	2791954..2792886	-	933	WP_000759682.1	exonuclease domain-containing protein	-
KTR68_RS13740	2792902..2793615	-	714	WP_001031454.1	XRE family transcriptional regulator	-
KTR68_RS13745	2793578..2793751	+	174	WP_001801500.1	hypothetical protein	-
KTR68_RS13750	2793748..2794011	+	264	WP_000854072.1	helix-turn-helix transcriptional regulator	-
KTR68_RS13755	2794027..2794242	+	216	WP_001025404.1	DUF2829 domain-containing protein	-
KTR68_RS13760	2794231..2794560	-	330	WP_000128907.1	hypothetical protein	-
KTR68_RS13765	2794611..2795367	+	757	Protein_2688	phage antirepressor KilAC domain-containing protein	-
KTR68_RS13770	2795383..2795580	+	198	WP_001148860.1	hypothetical protein	-
KTR68_RS13775	2795567..2795947	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
KTR68_RS13780	2796014..2796259	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
KTR68_RS13785	2796228..2796593	-	366	WP_001128433.1	hypothetical protein	Antitoxin
KTR68_RS13790	2796648..2796863	+	216	WP_001097552.1	hypothetical protein	-
KTR68_RS13795	2796890..2797153	+	264	WP_001124196.1	helix-turn-helix domain-containing protein	-
KTR68_RS13800	2797166..2797327	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
KTR68_RS13805	2797422..2797724	+	303	WP_001608484.1	DUF2482 family protein	-
KTR68_RS13810	2797729..2797989	+	261	WP_031584888.1	DUF1108 family protein	-
KTR68_RS13815	2797999..2798220	+	222	WP_000815401.1	DUF2483 family protein	-
KTR68_RS13820	2798213..2798836	+	624	WP_000139720.1	DUF1071 domain-containing protein	-
KTR68_RS13825	2798836..2799264	+	429	WP_031584877.1	single-stranded DNA-binding protein	-
KTR68_RS13830	2799278..2799952	+	675	WP_031584874.1	putative HNHc nuclease	-
KTR68_RS13835	2799945..2800697	+	753	WP_031584871.1	DnaD domain protein	-
KTR68_RS13840	2800697..2801053	+	357	WP_001132243.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T207722 WP_001025401.1 NZ_CP077757:2796014-2796259 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T207722 NZ_CP103494:c1650126-1649653 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTGACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGCAGTGGTGCAAACCAGTATGGCGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTAGCTTCACTGGAAATTCTGGTGCACGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCCGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
ACAAAGCACTCAATTCTGTTGAATTAATGCCTTTTAATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT207722 NZ_CP077757:c2796593-2796228 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin