Detailed information of TA system TA207717

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2575692..2575970
• Replicon: chromosome
• Accession: NZ_CP077757
• Organism: Staphylococcus aureus strain WHC07

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KTR68_RS12620
• Protein ID: WP_001802298.1
• Coordinates: 2575692..2575796 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2575792..2575970 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR68_RS12605	2572489..2573271	+	783	WP_031590911.1	ABC transporter ATP-binding protein	-
KTR68_RS12610	2573339..2574196	+	858	WP_000370930.1	HAD family hydrolase	-
KTR68_RS12615	2574854..2575012	-	159	WP_001792784.1	hypothetical protein	-
KTR68_RS12620	2575692..2575796	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2575792..2575970	-	179	-	-	Antitoxin
KTR68_RS12625	2576238..2577329	-	1092	WP_000495681.1	hypothetical protein	-
KTR68_RS12630	2577595..2578575	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
KTR68_RS12635	2578577..2578897	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KTR68_RS12640	2579049..2579714	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T207717 WP_001802298.1 NZ_CP077757:2575692-2575796 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T207717 NZ_CP103488:98229-98534 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT207717 NZ_CP077757:c2575970-2575792 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin