Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2318472..2318989 Replicon chromosome
Accession NZ_CP077757
Organism Staphylococcus aureus strain WHC07

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KTR68_RS11275 Protein ID WP_000113262.1
Coordinates 2318723..2318989 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KTR68_RS11270 Protein ID WP_000584499.1
Coordinates 2318472..2318723 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR68_RS11240 2314170..2314889 + 720 WP_000479576.1 amino acid ABC transporter permease -
KTR68_RS11245 2314886..2315617 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KTR68_RS11250 2315714..2316964 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
KTR68_RS11255 2317219..2317581 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KTR68_RS11260 2317600..2318199 + 600 WP_000162813.1 DsbA family protein -
KTR68_RS11265 2318206..2318307 + 102 WP_031774922.1 hypothetical protein -
KTR68_RS11270 2318472..2318723 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTR68_RS11275 2318723..2318989 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KTR68_RS14060 2319024..2319101 + 78 Protein_2201 hypothetical protein -
KTR68_RS11280 2319285..2320835 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KTR68_RS11285 2321021..2321488 + 468 WP_165621730.1 SRPBCC domain-containing protein -
KTR68_RS11290 2321572..2321754 + 183 WP_000230294.1 hypothetical protein -
KTR68_RS11295 2321971..2322795 + 825 WP_000572040.1 formate/nitrite transporter family protein -
KTR68_RS11300 2323028..2323564 + 537 WP_031585827.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T207715 WP_000113262.1 NZ_CP077757:2318723-2318989 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T207715 NZ_CP103487:c4805340-4805101 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGACCTATGAACTGGCGTTTGATCCGCGTGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGATCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGGTTGTGCAGAATCCGCGAATTGCATCGGCCAGTCTGAGTGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGGGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT207715 WP_000584499.1 NZ_CP077757:2318472-2318723 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT207715 NZ_CP103487:c4805572-4805330 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTGCGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCAGTGAAAAGTATGACTATCAGCGATA
GCGAAGCGGCATTATTACGCACCGTCCGCGAGCGGCTGGAAAACCCGCAGCCGGAGGTGAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References