Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2261510..2262033 Replicon chromosome
Accession NZ_CP077757
Organism Staphylococcus aureus strain WHC07

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag KTR68_RS11000 Protein ID WP_000074043.1
Coordinates 2261767..2262033 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag KTR68_RS10995 Protein ID WP_000587618.1
Coordinates 2261510..2261767 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR68_RS10975 2256583..2257776 + 1194 WP_000675407.1 MFS transporter -
KTR68_RS10980 2258007..2258756 - 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
KTR68_RS10985 2258951..2260528 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KTR68_RS10990 2260696..2261151 - 456 WP_000732076.1 DUF1307 domain-containing protein -
KTR68_RS10995 2261510..2261767 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTR68_RS11000 2261767..2262033 + 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
KTR68_RS11005 2262389..2263465 + 1077 WP_001076673.1 M42 family metallopeptidase -
KTR68_RS11010 2263713..2264375 + 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
KTR68_RS11015 2264368..2265144 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KTR68_RS11020 2265540..2266727 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T207712 WP_000074043.1 NZ_CP077757:2261767-2262033 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T207712 NZ_CP103487:1878888-1878990 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT207712 WP_000587618.1 NZ_CP077757:2261510-2261767 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT207712 NZ_CP103487:c1878994-1878847 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References