Detailed information of TA system TA207703

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2612849..2613127
• Replicon: chromosome
• Accession: NZ_CP077755
• Organism: Staphylococcus aureus strain WHC09

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KTR65_RS12830
• Protein ID: WP_001802298.1
• Coordinates: 2612849..2612953 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2612949..2613127 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR65_RS12810	2609646..2610428	+	783	WP_031590911.1	ABC transporter ATP-binding protein	-
KTR65_RS12815	2610496..2611353	+	858	WP_000370930.1	HAD family hydrolase	-
KTR65_RS12820	2612011..2612169	-	159	WP_001792784.1	hypothetical protein	-
KTR65_RS12825	2612162..2612332	-	171	WP_001792292.1	transposase	-
KTR65_RS12830	2612849..2612953	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2612949..2613127	-	179	-	-	Antitoxin
KTR65_RS12835	2613395..2614486	-	1092	WP_000495681.1	hypothetical protein	-
KTR65_RS12840	2614752..2615732	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
KTR65_RS12845	2615734..2616054	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KTR65_RS12850	2616206..2616871	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T207703 WP_001802298.1 NZ_CP077755:2612849-2612953 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T207703 NZ_CP103479:c4469294-4468953 [Escherichia coli]
ATGAAAATTATACCTGCAACGACGCTGCGGGCGACGACGTCATACCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGAC
CCGCCTACTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGAAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTACGGGCGCGACAGGCTACAGGTCTGCTGCGCCGCTG
CCATAACACCACGGCACGGTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT207703 NZ_CP077755:c2613127-2612949 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin