Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2355628..2356145 Replicon chromosome
Accession NZ_CP077755
Organism Staphylococcus aureus strain WHC09

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KTR65_RS11485 Protein ID WP_000113262.1
Coordinates 2355879..2356145 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KTR65_RS11480 Protein ID WP_000584499.1
Coordinates 2355628..2355879 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR65_RS11450 2351326..2352045 + 720 WP_000479576.1 amino acid ABC transporter permease -
KTR65_RS11455 2352042..2352773 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KTR65_RS11460 2352870..2354120 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
KTR65_RS11465 2354375..2354737 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KTR65_RS11470 2354756..2355355 + 600 WP_000162813.1 DsbA family protein -
KTR65_RS11475 2355362..2355463 + 102 WP_031774922.1 hypothetical protein -
KTR65_RS11480 2355628..2355879 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTR65_RS11485 2355879..2356145 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KTR65_RS14290 2356180..2356257 + 78 Protein_2244 hypothetical protein -
KTR65_RS11490 2356441..2357991 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KTR65_RS11495 2358177..2358644 + 468 WP_000153344.1 SRPBCC domain-containing protein -
KTR65_RS11500 2358728..2358910 + 183 WP_000230294.1 hypothetical protein -
KTR65_RS11505 2359127..2359951 + 825 WP_000572040.1 formate/nitrite transporter family protein -
KTR65_RS11510 2360184..2360720 + 537 WP_031585827.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T207701 WP_000113262.1 NZ_CP077755:2355879-2356145 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T207701 NZ_CP103479:4335452-4335604 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT207701 WP_000584499.1 NZ_CP077755:2355628-2355879 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT207701 NZ_CP103479:c4335403-4335346 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References