Detailed information of TA system TA207698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2298667..2299190
• Replicon: chromosome
• Accession: NZ_CP077755
• Organism: Staphylococcus aureus strain WHC09

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: KTR65_RS11210
• Protein ID: WP_000074043.1
• Coordinates: 2298924..2299190 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KTR65_RS11205
• Protein ID: WP_000587618.1
• Coordinates: 2298667..2298924 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR65_RS11185	2293740..2294933	+	1194	WP_000675407.1	MFS transporter	-
KTR65_RS11190	2295164..2295913	-	750	WP_000072466.1	CPBP family lipoprotein N-acylation protein LnsB	-
KTR65_RS11195	2296108..2297685	+	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KTR65_RS11200	2297853..2298308	-	456	WP_000732076.1	DUF1307 domain-containing protein	-
KTR65_RS11205	2298667..2298924	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KTR65_RS11210	2298924..2299190	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
KTR65_RS11215	2299546..2300622	+	1077	WP_001076673.1	M42 family metallopeptidase	-
KTR65_RS11220	2300870..2301532	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
KTR65_RS11225	2301525..2302301	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
KTR65_RS11230	2302697..2303884	+	1188	WP_000026194.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T207698 WP_000074043.1 NZ_CP077755:2298924-2299190 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T207698 NZ_CP103479:3842232-3842450 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT207698 WP_000587618.1 NZ_CP077755:2298667-2298924 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT207698 NZ_CP103479:3841832-3842206 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2