Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | SprG3-SprA2AS/- |
| Location | 2302123..2302321 | Replicon | chromosome |
| Accession | NZ_CP077741 | ||
| Organism | Staphylococcus aureus strain NL1 | ||
Toxin (Protein)
| Gene name | SprG3 | Uniprot ID | Q2FWA7 |
| Locus tag | KTE72_RS11500 | Protein ID | WP_001802298.1 |
| Coordinates | 2302217..2302321 (-) | Length | 35 a.a. |
Antitoxin (RNA)
| Gene name | SprA2AS | ||
| Locus tag | - | ||
| Coordinates | 2302123..2302161 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTE72_RS11475 (KTE72_11395) | 2298243..2298908 | - | 666 | WP_001024099.1 | SDR family oxidoreductase | - |
| KTE72_RS11480 (KTE72_11400) | 2299060..2299380 | + | 321 | WP_000003759.1 | Zn(II)-responsive metalloregulatory transcriptional repressor CzrA | - |
| KTE72_RS11485 (KTE72_11405) | 2299382..2300362 | + | 981 | WP_000019735.1 | CDF family zinc efflux transporter CzrB | - |
| KTE72_RS11490 (KTE72_11410) | 2300628..2301719 | + | 1092 | WP_000495673.1 | hypothetical protein | - |
| KTE72_RS11495 | 2302103..2302177 | + | 75 | Protein_2227 | hypothetical protein | - |
| - | 2302123..2302161 | + | 39 | - | - | Antitoxin |
| KTE72_RS11500 (KTE72_11415) | 2302217..2302321 | - | 105 | WP_001802298.1 | hypothetical protein | Toxin |
| KTE72_RS11505 (KTE72_11420) | 2303001..2303159 | + | 159 | WP_001792784.1 | hypothetical protein | - |
| KTE72_RS11510 (KTE72_11425) | 2303595..2303687 | + | 93 | WP_000220902.1 | hypothetical protein | - |
| KTE72_RS11515 (KTE72_11430) | 2303817..2304674 | - | 858 | WP_000370942.1 | HAD family hydrolase | - |
| KTE72_RS11520 (KTE72_11435) | 2304742..2305524 | - | 783 | WP_000908191.1 | ABC transporter ATP-binding protein | - |
| KTE72_RS11525 (KTE72_11440) | 2305814..2306422 | - | 609 | WP_000101714.1 | TIR domain-containing protein | - |
| KTE72_RS11530 (KTE72_11445) | 2306450..2306989 | - | 540 | WP_223596973.1 | toll/interleukin-1 receptor domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2307150..2308322 | 1172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 35 a.a. Molecular weight: 3906.77 Da Isoelectric Point: 5.5724
>T207690 WP_001802298.1 NZ_CP077741:c2302321-2302217 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
Download Length: 105 bp
>T207690 NZ_CP103479:1223912-1224247 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 39 bp
>AT207690 NZ_CP077741:2302123-2302161 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
