Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 372501..373080 | Replicon | chromosome |
| Accession | NZ_CP077741 | ||
| Organism | Staphylococcus aureus strain NL1 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | KTE72_RS01635 | Protein ID | WP_001025401.1 |
| Coordinates | 372501..372746 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 372715..373080 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTE72_RS01575 (KTE72_01560) | 368028..368174 | - | 147 | WP_001795334.1 | hypothetical protein | - |
| KTE72_RS01580 (KTE72_01565) | 368404..368988 | - | 585 | WP_000825948.1 | hypothetical protein | - |
| KTE72_RS01585 (KTE72_01570) | 369006..369467 | - | 462 | WP_000525004.1 | hypothetical protein | - |
| KTE72_RS01590 (KTE72_01575) | 369480..369794 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| KTE72_RS01595 (KTE72_01580) | 369946..370182 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| KTE72_RS01600 (KTE72_01585) | 370196..370972 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| KTE72_RS01605 (KTE72_01590) | 371001..371150 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| KTE72_RS01610 (KTE72_01595) | 371191..371403 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| KTE72_RS01615 (KTE72_01600) | 371473..371670 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| KTE72_RS01620 (KTE72_01605) | 371657..372007 | - | 351 | WP_031795353.1 | DUF2513 domain-containing protein | - |
| KTE72_RS01625 (KTE72_01610) | 372103..372246 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| KTE72_RS01630 (KTE72_01615) | 372236..372445 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| KTE72_RS01635 (KTE72_01620) | 372501..372746 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| KTE72_RS01640 (KTE72_01625) | 372715..373080 | - | 366 | WP_031795354.1 | hypothetical protein | Antitoxin |
| KTE72_RS01645 (KTE72_01630) | 373135..373350 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| KTE72_RS01650 (KTE72_01635) | 373375..373638 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| KTE72_RS01655 (KTE72_01640) | 373651..373812 | + | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
| KTE72_RS01660 (KTE72_01645) | 373891..374214 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| KTE72_RS01665 (KTE72_01650) | 374229..374591 | + | 363 | WP_000985976.1 | hypothetical protein | - |
| KTE72_RS01670 (KTE72_01655) | 374588..375754 | + | 1167 | WP_031863984.1 | DUF2800 domain-containing protein | - |
| KTE72_RS01675 (KTE72_01660) | 375780..376337 | + | 558 | WP_000645045.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 366086..412432 | 46346 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T207683 WP_001025401.1 NZ_CP077741:372501-372746 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T207683 NZ_CP103470:2266-2541 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 366 bp
>AT207683 NZ_CP077741:c373080-372715 [Staphylococcus aureus]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
