Detailed information of TA system TA207672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1902715..1903461
• Replicon: chromosome
• Accession: NZ_CP077723
• Organism: Pasteurella multocida strain PMWSG-4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KSF84_RS08930
• Protein ID: WP_061406326.1
• Coordinates: 1902715..1903041 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KSF84_RS08935
• Protein ID: WP_005757699.1
• Coordinates: 1903135..1903461 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF84_RS08905 (KSF84_08905)	1898032..1898718	+	687	WP_061406323.1	hypothetical protein	-
KSF84_RS08910 (KSF84_08910)	1898772..1900301	-	1530	WP_061406324.1	YifB family Mg chelatase-like AAA ATPase	-
KSF84_RS08915 (KSF84_08915)	1900410..1901027	-	618	WP_005724253.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
KSF84_RS08920 (KSF84_08920)	1901138..1902007	+	870	WP_061406325.1	VirK/YbjX family protein	-
KSF84_RS08925 (KSF84_08925)	1902081..1902557	-	477	WP_042742721.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KSF84_RS08930 (KSF84_08930)	1902715..1903041	+	327	WP_061406326.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KSF84_RS08935 (KSF84_08935)	1903135..1903461	+	327	WP_005757699.1	HigA family addiction module antitoxin	Antitoxin
KSF84_RS08940 (KSF84_08940)	1903516..1905036	-	1521	WP_061406327.1	surface lipoprotein assembly modifier	-
KSF84_RS08945 (KSF84_08945)	1905095..1905685	-	591	WP_061406438.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
KSF84_RS08950 (KSF84_08950)	1905748..1906758	-	1011	WP_061406328.1	hypothetical protein	-
KSF84_RS08955 (KSF84_08955)	1906994..1908025	-	1032	WP_061406329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (12-104)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-102)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12923.75 Da
• Isoelectric Point: 9.6705

>T207672 WP_061406326.1 NZ_CP077723:1902715-1903041 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Nucleotide

• Length: 327 bp

>T207672 NZ_CP103468:3356110-3356496 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12377.41 Da
• Isoelectric Point: 7.2034

>AT207672 WP_005757699.1 NZ_CP077723:1903135-1903461 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Nucleotide

• Length: 327 bp

>AT207672 NZ_CP103468:3356486-3356815 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA