Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4703461..4704215 | Replicon | chromosome |
| Accession | NZ_CP077711 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058606 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | DAX63_RS22850 | Protein ID | WP_000558166.1 |
| Coordinates | 4703461..4703772 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DAX63_RS22855 | Protein ID | WP_001259012.1 |
| Coordinates | 4703769..4704215 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX63_RS22820 (4699127) | 4699127..4700029 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| DAX63_RS22825 (4700026) | 4700026..4700661 | + | 636 | WP_108429743.1 | formate dehydrogenase cytochrome b556 subunit | - |
| DAX63_RS22830 (4700658) | 4700658..4701587 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| DAX63_RS22835 (4701625) | 4701625..4701999 | - | 375 | WP_000238496.1 | type II toxin-antitoxin system VapC family toxin | - |
| DAX63_RS22840 (4701999) | 4701999..4702241 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| DAX63_RS22845 (4702446) | 4702446..4703375 | + | 930 | WP_001162863.1 | alpha/beta hydrolase fold domain-containing protein | - |
| DAX63_RS22850 (4703461) | 4703461..4703772 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| DAX63_RS22855 (4703769) | 4703769..4704215 | + | 447 | WP_001259012.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| DAX63_RS22860 (4704230) | 4704230..4705171 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| DAX63_RS22865 (4705216) | 4705216..4705653 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| DAX63_RS22870 (4705650) | 4705650..4706522 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| DAX63_RS22875 (4706516) | 4706516..4707115 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| DAX63_RS22880 (4707306) | 4707306..4708109 | - | 804 | WP_023240394.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| DAX63_RS22885 (4708143) | 4708143..4709039 | - | 897 | WP_001736115.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T207658 WP_000558166.1 NZ_CP077711:4703461-4703772 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T207658 NZ_CP103466:120718-121023 [Escherichia coli O25b:H4-ST131]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16750.08 Da Isoelectric Point: 6.6451
>AT207658 WP_001259012.1 NZ_CP077711:4703769-4704215 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT207658 NZ_CP103466:120498-120716 [Escherichia coli O25b:H4-ST131]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|