Detailed information of TA system TA207642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 2074017..2074545
• Replicon: chromosome
• Accession: NZ_CP077711
• Organism: Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DAX63_RS23905
• Protein ID: WP_108429764.1
• Coordinates: 2074315..2074545 (-)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAX63_RS23900
• Protein ID: WP_000147078.1
• Coordinates: 2074017..2074325 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX63_RS10075 (2069569)	2069569..2070396	-	828	WP_023223560.1	DUF2303 family protein	-
DAX63_RS10080 (2070454)	2070454..2070825	-	372	WP_000997190.1	hypothetical protein	-
DAX63_RS10085 (2071362)	2071362..2071700	+	339	WP_108429762.1	hypothetical protein	-
DAX63_RS10090 (2071638)	2071638..2071946	-	309	WP_108429763.1	hypothetical protein	-
DAX63_RS10095 (2072121)	2072121..2072795	-	675	WP_001749159.1	LexA family transcriptional regulator	-
DAX63_RS10100 (2072884)	2072884..2073084	+	201	WP_001749160.1	YdaS family helix-turn-helix protein	-
DAX63_RS10105 (2073128)	2073128..2073682	+	555	WP_023139406.1	YmfL family putative regulatory protein	-
DAX63_RS23895 (2073822)	2073822..2073998	+	177	WP_001525520.1	DUF4222 domain-containing protein	-
DAX63_RS23900 (2074017)	2074017..2074325	-	309	WP_000147078.1	helix-turn-helix transcriptional regulator	Antitoxin
DAX63_RS23905 (2074315)	2074315..2074545	-	231	WP_108429764.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DAX63_RS23910 (2074510)	2074510..2075508	+	999	WP_108429770.1	Rha family phage regulatory protein	-
DAX63_RS10115 (2075505)	2075505..2075729	+	225	WP_000620702.1	hypothetical protein	-
DAX63_RS10120 (2075726)	2075726..2076670	+	945	WP_000104925.1	helix-turn-helix domain-containing protein	-
DAX63_RS10125 (2076672)	2076672..2077154	+	483	WP_023171062.1	PerC family transcriptional regulator	-
DAX63_RS10130 (2077154)	2077154..2078032	+	879	WP_046722474.1	phage N-6-adenine-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2066507..2091915	25408

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (5-70)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-94)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 8640.11 Da
• Isoelectric Point: 10.5308

>T207642 WP_108429764.1 NZ_CP077711:c2074545-2074315 [Salmonella enterica subsp. enterica]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW

Nucleotide

• Length: 231 bp

>T207642 NZ_CP103465:1931373-1931624 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11110.77 Da
• Isoelectric Point: 7.0152

>AT207642 WP_000147078.1 NZ_CP077711:c2074325-2074017 [Salmonella enterica subsp. enterica]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV

Nucleotide

• Length: 309 bp

>AT207642 NZ_CP103465:1931621-1931875 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA